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Furthermore, on encounter with a stress stimulus, a ROS-linked peculiar signal obstructs both cellular division and proliferation

Yamauchi, M., Terajima, M

When cancer occurs, the Hippo signaling becomes inactive, the unphosphorylated yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ) enters the nucleus, and binds to the transcriptional enhanced associate domains (TEADs) transcription family, synergistically promoting the expression of target genes, enhancing cell proliferation, resistance to apoptosis, invasion and metastasis

The exact pathogenic mechanisms of ALS have not been fully elucidated

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