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When the disease starts during infancy or childhood, it's usually more severe and life expectancy is shorter.

Previous studies suggested that such nanoparticles can be involved in cytotoxicity, oxidative stress, and genotoxic alterations within biological systems (314)

Crude cell extracts from a broad range of organisms have been employed

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Expression could be achieved using adenoassociated virus vectors/marrow stromal cells (MSCs) or nonviral intravenous agents involving rat transferrin receptor monoclonal antibodies (TfRmAb) targeted to PE glycated immunoliposomes