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Description
the pigmented RPE cells become defective, and die, resulting in a functional loss of PEDF in the macula

An imbalance between the pro-death and pro-survival proteins (also known as pro-apoptotic and anti-apoptotic proteins, respectively) can trigger downstream proteins in this pathway, leading to DNA fragmentation and cell death

10.1038/nature09922 8

Gejalanya seperti tremor serta otot terasa kaku

World Obesity Atlas
