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Children under 12, seniors over 65, pregnant and lactating women should always consult with a physician or healthcare professional prior to use
The synovium can secrete proinflammatory cytokines, leading to cartilage damage
Developing delivery systems that exploit the unique microenvironment of the female reproductive system, such as pH sensitivity or enzyme-specific activation, could improve localization and reduce off-target effects
However, the use of TNF- blockers significantly increases the risk of Mtb infection
