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While in animals it mediates neurotransmission, neuromodulation, and synaptic plasticity, in plants it regulates seed germination, root development, stomatal closure, and floral transition (Forrester et al

doi: 10.3389/fped.2018.00373 194 Nagy-SzakalDWilliamsBLMishraNCheXLeeBBatemanLet al

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Loading Phase Initial period of higher-frequency dosing designed to build tissue concentrations quickly

Growing evidence indicates that dietary herbs can modulate gut microbiota composition and generate bioactive metabolites that mitigate inflammation, oxidative stress, and apoptosis following stroke, underscoring a promising gut-mediated mechanism for herbal interventions (Li X