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JAMA Neurol 2019;76:420429.ArticlePubMedPMC 114

The most serious adverse eventpancreatitis, or pancreas inflammationoccurs in only 0.1 percent of patients, making it highly unlikely

So far, researchers have understood that side effects, including gastric upset and nausea, tend to occur at the beginning of treatment, but a review of the available literature suggested that the weight loss in the early stages of using the drug, was not linked to nausea

Data regarding average weight loss outcomes is derived from self-reported patient surveys and testimonials, not controlled clinical research with independent verification or peer review

Quick Answer: Feeling cold on Wegovy is often caused by a combination of rapid fat loss (losing insulation), a lower caloric intake (less fuel for heat), and the medications effect on the hypothalamus, which regulates body temperature