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The JAMA Network Open Study Study Design Database: TriNetX, which contains records from millions of U.S

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Preclinical evidence suggests that increasing protein intake may offset circulating amino-acids reduction, however this may also blunt the increase in whole-body energy expenditure [63]

Another meta-analysis conducted on adolescents with overweight/obesity without T2D reported that GLP-1RAs had a better anti-obesity effect when compared to placebo or lifestyle modification (semaglutide is better than liraglutide and exenatide for weight control) [35]

Mechanistically, liraglutide and semaglutide decreased LV hypertrophy and fibrosis, and improved diastolic dysfunction, lung congestion, and exercise capacity