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For the right patient, that can still be worthwhile

How GLP-1 Medications Work in the Body Appetite Regulation and Satiety GLP-1 medications work by mimicking the action of glucagon-like peptide-1, a hormone naturally released after eating

Fermented foods to increase the good bacteria in the gut Fermented foods like kimchi, kefir, kombucha, and sauerkraut not only increase butyrate production but help to create a more balanced gut microbiome which has been shown to enhance GLP-1 production

Shah S, Schutte-Rodin S, Paruthi S, et al

Metformin contributes to weight loss by decreasing glucose production and helping your body use its own insulin more effectively