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Compared with DPP-4 inhibitors, the lower rate of hyperkalemia was consistently observed across individual agents in the SGLT-2 inhibitor (canagliflozin, dapagliflozin, empagliflozin) and GLP-1 receptor agonist (dulaglutide, exenatide, liraglutide, semaglutide) classes

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Strategic implications: For healthcare executives and policy leaders, this signals evolving payer conversations, updated treatment guidelines, and new opportunitiesbut also demands close attention to long-term efficacy and safety data