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Gary further noted that adipose tissue is metabolically active and can affect estrogen production and inflammatory signaling, both of which are involved in breast cancer biology

The STEP trials showed sustained weight loss only while participants remained on active medication, with most regaining 50% or more of lost weight after discontinuation

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That may include lab review, physician evaluation, lifestyle coaching, and consideration of whether additional interventions are needed if weight loss plateaus or if other health concerns are involved

Rebosio C, Balbi M, Passalacqua M, Ricciarelli R, Fedele E