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Most patients notice appetite regulation within a few weeks, with visible weight loss typically starting around one to two months into treatment

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Shen AS et al

Curcumin Compensates GLP-1 Deficiency via the Microbiota-Bile Acids Axis and Modulation in Functional Crosstalk between TGR5 and FXR in ob/ob Mice

Despite the demonstrable importance of surveillance of lean mass during testing of obesity drug candidates, it is common for only fat mass loss or total body weight loss to be measured or presented in pre-clinical and early clinical trials