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Adolescents with a BMI of 95th percentile or higher may also be eligible for the treatment starting at age 12

Per HumeCare's Medications Safety Information, these medications should not be used during pregnancy, based on potential risks identified in animal studies, and there is no established weight-loss benefit that would justify use during pregnancy

Several systematic reviews on subcutaneous semaglutide or oral semaglutide have recently been published, but their focus is primarily on efficacy and safety, rather than pharmacokinetics.6466 In addition, a few of population pharmacokinetic models were established using data from selected clinical pharmacological trials to identify clinically relevant covariates of exposure, but they included limited trial data.50,53,54 The limitation of this review is that we only searched two databases, so it is possible that we missed one study, which may reduce the validity and subsequent reliability of the findings

In the United Kingdom, the National Institute for Health and Care Excellence (NICE) has provided guidance to the National Health Service (NHS) regarding cost effective use of novel AOMs, prioritizing patients with higher BMI and related complications, thereby limiting access for those with less complicated obesity (171)

The eligibility depends on BMI, comorbidities, and clinician assessment